MTUS1 Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. Belongs to the MTUS1 family. Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Tumor suppressor
Chromosomal Location of mouse Ortholog: 8|8 A4
Cellular Component:  cytoplasm; Golgi apparatus; membrane; microtubule cytoskeleton; mitochondrion; nucleolus; nucleus; plasma membrane
Molecular Function:  microtubule binding
Biological Process:  cell cycle; regulation of macrophage chemotaxis
Reference #:  Q5HZI1 (UniProtKB)
Alt. Names/Synonyms: AI481402; angiotensin II AT2 receptor-interacting protein 1; Angiotensin-II type 2 receptor-interacting protein; AT2 receptor-binding protein; AT2 receptor-interacting protein 1; Atbp; ATBP135; Atip; Atip1; B430010I23Rik; B430305I03Rik; C85752; Cctsg1; Cctsg1-440; Coiled-coiled tumor suppressor gene 1 protein; coiled-coiled tumor supressor gene 1; Kiaa1288; MD44; MGC115798; Microtubule-associated tumor suppressor 1 homolog; mitochondrial tumor suppressor 1; Mitochondrial tumor suppressor 1 homolog; mKIAA1288; MTSG; Mtsg1; Mtus1
Gene Symbols: Mtus1
Molecular weight: 134,379 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene