MAGOH Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Remains associated with the mRNA after its export to the cytoplasm and require translation of the mRNA for removal. The heterodimer MAGOH-RBM8A interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Belongs to the mago nashi family. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; Spliceosome
Chromosomal Location of Human Ortholog: 4 C7|4 50.18 cM
Cellular Component:  catalytic step 2 spliceosome; cytoplasm; exon-exon junction complex; nucleus; spliceosomal complex
Molecular Function:  RNA binding
Biological Process:  female gamete generation; mRNA processing; mRNA transport; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; regulation of alternative mRNA splicing, via spliceosome; regulation of translation; RNA splicing
Reference #:  P61327 (UniProtKB)
Alt. Names/Synonyms: Mago-m; mago-nashi homolog, proliferation-associated (Drosophila); Magoh; MGN; OTTMUSP00000009528; Protein mago nashi homolog
Gene Symbols: Magoh
Molecular weight: 17,164 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
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MAGOH

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene