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Tyro3
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. Abundant in the brain and lower levels in other tissues. Note: This description may include information from UniProtKB.
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| Protein type: Axl family; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group |
| Chromosomal Location of human Ortholog: 15q15.1 |
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Cellular Component:
cell surface; endoplasmic reticulum membrane; integral component of plasma membrane; nuclear envelope; nucleus
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Molecular Function:
ATP binding; phosphatidylinositol 3-kinase binding; protein binding; protein heterodimerization activity; protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; virus receptor activity
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Biological Process:
apoptotic cell clearance; cell adhesion; forebrain cell migration; natural killer cell differentiation; negative regulation of inflammatory response; negative regulation of innate immune response; negative regulation of lymphocyte activation; negative regulation of neuron apoptotic process; negative regulation of toll-like receptor signaling pathway; neuron cellular homeostasis; neuropeptide signaling pathway; ovulation cycle; peptidyl-tyrosine phosphorylation; phosphatidylinositol 3-kinase signaling; platelet activation; platelet aggregation; protein autophosphorylation; protein kinase B signaling; secretion by cell; signal transduction; spermatogenesis; substrate adhesion-dependent cell spreading; vagina development; viral entry into host cell
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Reference #:
Q06418
(UniProtKB)
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Alt. Names/Synonyms: Brt; BYK; DTK; Etk-2; FLJ16467; Rek; RSE; SKY; Tif; TYRO3; TYRO3 protein tyrosine kinase; Tyro3 protein tyrosine kinase (sea-related receptor tyrosine kinase); Tyrosine-protein kinase byk; Tyrosine-protein kinase DTK; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF
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Gene Symbols: TYRO3
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Molecular weight:
96,905 Da
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Basal Isoelectric point:
5.47
Predict pI for various phosphorylation states
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CST Pathways:
Tyrosine Kinases & Substrates
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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