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TKTL2
Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis. Belongs to the transketolase family. Overexpressed in hepatoma cancer cells. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - pentose phosphate pathway; EC 2.2.1.1; Transferase |
| Chromosomal Location of mouse Ortholog: 8|8 B3.1 |
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Cellular Component:
cytoplasm
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Molecular Function:
catalytic activity; metal ion binding; thiamine pyrophosphate binding; transferase activity; transketolase activity
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Reference #:
Q9D4D4
(UniProtKB)
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Alt. Names/Synonyms: 4933401I19Rik; Tktl2; transketolase-like 2; Transketolase-like protein 2
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Gene Symbols: Tktl2
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Molecular weight:
68,447 Da
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Basal Isoelectric point:
6.51
Predict pI for various phosphorylation states
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