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TKTL2
Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis. Belongs to the transketolase family. Overexpressed in hepatoma cancer cells. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - pentose phosphate pathway; EC 2.2.1.1; Transferase |
| Chromosomal Location of human Ortholog: 4q32.2 |
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Cellular Component:
cytoplasm
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Molecular Function:
metal ion binding; thiamine pyrophosphate binding; transketolase activity
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Reference #:
Q9H0I9
(UniProtKB)
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Alt. Names/Synonyms: DKFZp434L1717; FLJ32975; testis tissue sperm-binding protein Li 39a; TKTL2; transketolase like 2; transketolase-like 2; Transketolase-like protein 2
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Gene Symbols: TKTL2
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Molecular weight:
67,877 Da
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Basal Isoelectric point:
5.9
Predict pI for various phosphorylation states
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