TKTL2 Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis. Belongs to the transketolase family. Overexpressed in hepatoma cancer cells. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - pentose phosphate pathway; EC; Transferase
Chromosomal Location of Human Ortholog: 4q32.2
Cellular Component:  cytoplasm
Molecular Function:  metal ion binding; transketolase activity
Reference #:  Q9H0I9 (UniProtKB)
Alt. Names/Synonyms: DKFZp434L1717; FLJ32975; testis tissue sperm-binding protein Li 39a; TKTL2; transketolase like 2; transketolase-like 2; Transketolase-like protein 2
Gene Symbols: TKTL2
Molecular weight: 67,877 Da
Basal Isoelectric point: 5.9  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene