GPR126
G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling. May act as a receptor for PRNP which may promote myelin homeostasis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
Chromosomal Location of mouse Ortholog: 10|10 A2 |
Cellular Component:
cell surface; cytoplasm; membrane; plasma membrane
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Molecular Function:
G protein-coupled receptor activity; laminin binding; protein binding; transmembrane signaling receptor activity
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Biological Process:
adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP-mediated signaling; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; heart trabecula formation; mitochondrion organization; myelination; myelination in peripheral nervous system; Schwann cell differentiation; signal transduction
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Reference #:
Q6F3F9
(UniProtKB)
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Alt. Names/Synonyms: 1190004A11Rik; Adgrg6; ADGRG6 C-terminal fragment; ADGRG6 N-terminal fragment; ADGRG6-CTF; ADGRG6-NTF; adhesion G protein-coupled receptor G6; Adhesion G-protein coupled receptor G6; AGRG6; AI449247; AW045736; Developmentally regulated G-protein-coupled receptor; DRE; Dreg; G protein coupled receptor Gpr126; G protein-coupled receptor 126; G-protein coupled receptor 126; Gm222; GP126; Gpr1; Gpr126; probable G-protein coupled receptor 126
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Gene Symbols: Adgrg6
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Molecular weight:
129,721 Da
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Basal Isoelectric point:
6.26
Predict pI for various phosphorylation states
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