GPR126 G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling. May act as a receptor for PRNP which may promote myelin homeostasis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 10|10 A2
Cellular Component:  cell surface; cytoplasm; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane
Molecular Function:  G protein-coupled receptor activity; laminin binding; protein binding; transmembrane signaling receptor activity
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP-mediated signaling; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; heart trabecula formation; mitochondrion organization; myelination; myelination in peripheral nervous system; Schwann cell differentiation; signal transduction
Reference #:  Q6F3F9 (UniProtKB)
Alt. Names/Synonyms: 1190004A11Rik; Adhesion G-protein coupled receptor G6; AI449247; AW045736; Developmentally regulated G-protein-coupled receptor; Dreg; G protein-coupled receptor 126; G-protein coupled receptor 126; Gm222; GP126; Gpr126; probable G-protein coupled receptor 126
Gene Symbols: Gpr126
Molecular weight: 129,721 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene