| TTK Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Present in rapidly proliferating cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB. |
| Protein type: Cancer Testis Antigen (CTA); EC 2.7.12.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor); TTK family |
| Chromosomal Location of human Ortholog: 6q14.1 |
| Cellular Component: cytoplasm; kinetochore; nucleus; spindle |
| Molecular Function: ATP binding; identical protein binding; kinetochore binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity |
| Biological Process: chromosome segregation; female meiosis chromosome segregation; meiotic spindle assembly checkpoint signaling; mitotic spindle assembly checkpoint signaling; mitotic spindle organization; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of cell population proliferation; positive regulation of pathway-restricted SMAD protein phosphorylation; protein autophosphorylation; protein localization to kinetochore; protein localization to meiotic spindle midzone; spindle organization |
| Reference #: P33981 (UniProtKB) |
| Alt. Names/Synonyms: cancer/testis antigen 96; CT96; Dual specificity protein kinase TTK; ESK; FLJ38280; monopolar spindle 1 kinase; monopolar spindle 1-like 1; MPH1; MPS1; MPS1L1; phosphotyrosine picked threonine kinase; Phosphotyrosine picked threonine-protein kinase; PYT; TTK; TTK protein kinase |
| Gene Symbols: TTK |
| Molecular weight: 97,072 Da |
| Basal Isoelectric point: 8.41 Predict pI for various phosphorylation states |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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TTK |
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