latrophilin 2 Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of mouse Ortholog: 3|3 H3
Cellular Component:  glutamatergic synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic membrane; membrane; neuron projection
Molecular Function:  carbohydrate binding; G protein-coupled receptor activity; PDZ domain binding; transmembrane signaling receptor activity
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; brain development; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; positive regulation of synapse assembly; response to bacterium; signal transduction; synapse organization
Reference #:  Q8JZZ7 (UniProtKB)
Alt. Names/Synonyms: Adgrl2; Adhesion G protein-coupled receptor L2; AGRL2; AI450192; Calcium-independent alpha-latrotoxin receptor 2; calcium-independent alpha-latrotoxin receptor homolog 2; CIRL-2; G protein coupled receptor Lec1; Gm619; Kiaa0786; latrophilin 1; latrophilin 2; Latrophilin-2; Lec; Lec1; Lph; Lphh1; Lphn2; MGC38872; mKIAA0786
Gene Symbols: Adgrl2
Molecular weight: 166,577 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
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latrophilin 2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein