latrophilin 2 Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 1p31.1
Cellular Component:  membrane
Molecular Function:  carbohydrate binding; G protein-coupled receptor activity; latrotoxin receptor activity
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway
Reference #:  O95490 (UniProtKB)
Alt. Names/Synonyms: ADGRL2; Adhesion G protein-coupled receptor L2; AGRL2; Calcium-independent alpha-latrotoxin receptor 2; CIRL-2; CIRL2; CL2; KIAA0786; latrophilin 1; latrophilin 2; Latrophilin homolog 1; latrophilin homolog 2 (cow); Latrophilin-2; LEC1; Lectomedin-1; LPHH1; LPHN2
Gene Symbols: ADGRL2
Molecular weight: 163,349 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
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latrophilin 2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein