MAN1 Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. Heart, brain, placenta, lung, liver and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Nuclear envelope
Chromosomal Location of Human Ortholog: 10|10 D2
Cellular Component:  integral component of membrane; integral component of nuclear inner membrane; membrane; nuclear envelope; nuclear inner membrane; nuclear membrane; nucleus
Molecular Function:  DNA binding; nucleic acid binding
Biological Process:  angiogenesis; blood vessel endothelial cell migration involved in intussusceptive angiogenesis; negative regulation of activin receptor signaling pathway; negative regulation of BMP signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; nuclear envelope organization; nucleus organization; regulation of cell cycle; regulation of extracellular matrix organization; regulation of intracellular signal transduction; skeletal muscle cell differentiation
Reference #:  Q9WU40 (UniProtKB)
Alt. Names/Synonyms: AI316861; Inner nuclear membrane protein Man1; integral inner nuclear membrane protein MAN1; LEM domain containing 3; LEM domain-containing protein 3; Lemd3; Man1
Gene Symbols: Lemd3
Molecular weight: 100,307 Da
Basal Isoelectric point: 7.33  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene