MAN1
Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. Heart, brain, placenta, lung, liver and skeletal muscle. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral; Membrane protein, multi-pass; Nuclear envelope |
Chromosomal Location of mouse Ortholog: 10|10 D2 |
Cellular Component:
membrane; nuclear envelope; nuclear inner membrane; nuclear membrane; nucleus
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Molecular Function:
chromatin DNA binding; DNA binding; nucleic acid binding
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Biological Process:
angiogenesis; blood vessel endothelial cell migration involved in intussusceptive angiogenesis; negative regulation of activin receptor signaling pathway; negative regulation of BMP signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; nuclear envelope organization; nucleus organization; regulation of cell cycle; regulation of extracellular matrix organization; skeletal muscle cell differentiation
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Reference #:
Q9WU40
(UniProtKB)
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Alt. Names/Synonyms: AI316861; Inner nuclear membrane protein Man1; integral inner nuclear membrane protein MAN1; LEM domain containing 3; LEM domain-containing protein 3; Lemd3; Man1
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Gene Symbols: Lemd3
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Molecular weight:
100,307 Da
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Basal Isoelectric point:
7.33
Predict pI for various phosphorylation states
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