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DYX1C1
Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Expressed in several tissues, including brain, lung, kidney and testis. In brain localizes to a fraction of cortical neurons and white matter glial cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 9|9 D |
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Cellular Component:
cell projection; centrosome; cytoplasm; cytosol; non-motile cilium; nucleus; plasma membrane
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Molecular Function:
nuclear estrogen receptor binding; protein binding
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Biological Process:
cilium movement; determination of left/right symmetry; epithelial cilium movement involved in extracellular fluid movement; establishment of localization in cell; heart development; inner dynein arm assembly; learning or memory; nervous system development; neuron migration; outer dynein arm assembly; regulation of intracellular estrogen receptor signaling pathway; regulation of proteasomal protein catabolic process
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Reference #:
Q8R368
(UniProtKB)
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Alt. Names/Synonyms: 1700010I24Rik; b2b811.1Clo; b2b811C; b2b811Clo; DAAF4; Dnaaf4; Dynein assembly factor 4, axonemal; Dynein axonemal assembly factor 4; dyslexia susceptibility 1 candidate 1 homolog; dyslexia susceptibility 1 candidate 1 homolog (human); Dyslexia susceptibility 1 candidate gene 1 protein homolog; Dyx1c1; DYXC1; EKN; Ekn1
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Gene Symbols: Dnaaf4
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Molecular weight:
48,125 Da
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Basal Isoelectric point:
8.85
Predict pI for various phosphorylation states
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