DYX1C1 Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Expressed in several tissues, including brain, lung, kidney and testis. In brain localizes to a fraction of cortical neurons and white matter glial cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 15q21.3
Cellular Component:  centrosome; cytoplasm; cytosol; dynein axonemal particle; extracellular region; neuron projection; non-motile cilium; nucleus; plasma membrane
Molecular Function:  nuclear estrogen receptor binding; protein binding
Biological Process:  cilium movement; determination of left/right symmetry; epithelial cilium movement involved in extracellular fluid movement; establishment of localization in cell; heart development; inner dynein arm assembly; learning or memory; neuron migration; outer dynein arm assembly; regulation of intracellular estrogen receptor signaling pathway; regulation of proteasomal protein catabolic process
Disease: Ciliary Dyskinesia, Primary, 25; Dyslexia, Susceptibility To, 1
Reference #:  Q8WXU2 (UniProtKB)
Alt. Names/Synonyms: CILD25; DAAF4; DNAAF4; Dynein assembly factor 4, axonemal; dynein axonemal assembly factor 4; dyslexia susceptibility 1 candidate 1; Dyslexia susceptibility 1 candidate gene 1 protein; DYX1; DYX1C1; DYXC1; EKN1; FLJ37882; MGC70618; RD
Gene Symbols: DNAAF4
Molecular weight: 48,527 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein