kalirin Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle. 6 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC; GEF; GEF, Rac/Rho; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trio family
Chromosomal Location of Human Ortholog: 3q21.1-q21.2
Cellular Component:  actin cytoskeleton; cytosol; nucleoplasm
Molecular Function:  ATP binding; guanyl-nucleotide exchange factor activity; metal ion binding; protein serine/threonine kinase activity; Rho guanyl-nucleotide exchange factor activity
Biological Process:  adult locomotory behavior; ephrin receptor signaling pathway; G protein-coupled receptor signaling pathway; habituation; intracellular signal transduction; lactation; maternal behavior; maternal process involved in parturition; memory; negative regulation of growth hormone secretion; nervous system development; neuromuscular junction development; positive regulation of apoptotic process; positive regulation of dendritic spine morphogenesis; positive regulation of GTPase activity; protein phosphorylation; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; signal transduction; social behavior; vesicle-mediated transport
Disease: Coronary Heart Disease, Susceptibility To, 5
Reference #:  O60229 (UniProtKB)
Alt. Names/Synonyms: ARHGEF24; DUET; DUO; FLJ12332; FLJ16443; FLJ18196; FLJ18623; HAPIP; huntingtin-associated protein interacting protein (duo); Huntingtin-associated protein-interacting protein; Kalirin; kalirin, RhoGEF kinase; KALRN; Protein Duo; serine/threonine kinase with Dbl- and pleckstrin homology domains; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain; TRAD
Gene Symbols: KALRN
Molecular weight: 340,261 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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