LRPPRC May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA. Expressed ubiquitously. Expression is highest in heart, skeletal muscle, kidney and liver, intermediate in brain, non-mucosal colon, spleen and placenta, and lowest in small intestine, thymus, lung and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 17|17 E4
Cellular Component:  condensed nuclear chromosome; cytoplasm; cytoskeleton; membrane; microtubule; mitochondrial nucleoid; mitochondrion; nucleus; perinuclear region of cytoplasm; ribonucleoprotein complex
Molecular Function:  beta-tubulin binding; DNA binding; protein binding; RNA binding; single-stranded DNA binding; ubiquitin protein ligase binding
Biological Process:  mRNA transport; negative regulation of mitochondrial RNA catabolic process; regulation of mitochondrial translation
Reference #:  Q6PB66 (UniProtKB)
Alt. Names/Synonyms: 130 kDa leucine-rich protein; 3110001K13Rik; C76645; GP130; leucine rich protein LRP130; Leucine-rich PPR motif-containing protein, mitochondrial; leucine-rich PPR-motif containing; LPPRC; Lrp; LRP 130; Lrp130; Lrpprc; LSFC; mLRP130
Gene Symbols: Lrpprc
Molecular weight: 156,615 Da
Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states
Select Structure to View Below

LRPPRC

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene