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ROBO3
Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1. Required for hindbrain axon midline crossing. Belongs to the immunoglobulin superfamily. ROBO family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
| Chromosomal Location of mouse Ortholog: 9|9 A4 |
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Cellular Component:
axon; membrane; neuron projection; plasma membrane
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Molecular Function:
protein binding
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Biological Process:
axon guidance; axon midline choice point recognition; cell differentiation; chemotaxis; multicellular organism development; nervous system development; neuron migration; positive regulation of axon guidance
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Reference #:
Q9Z2I4
(UniProtKB)
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Alt. Names/Synonyms: Rbi; Rbig1; retinoblastoma inhibiting gene 1; Retinoblastoma-inhibiting gene 1 protein; Rig; Rig-1; Rig1; Rob; Robo3; Robo3a; Robo3b; roundabout guidance receptor 3; Roundabout homolog 3; roundabout homolog 3 (Drosophila)
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Gene Symbols: Robo3
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Molecular weight:
149,899 Da
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Basal Isoelectric point:
7.32
Predict pI for various phosphorylation states
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CST Pathways:
Angiogenesis
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