ROBO3 Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1. Required for hindbrain axon midline crossing. Belongs to the immunoglobulin superfamily. ROBO family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of human Ortholog: 11q24.2
Cellular Component:  axon; membrane; plasma membrane
Molecular Function:  cell-cell adhesion mediator activity; protein binding
Biological Process:  axon guidance; axon midline choice point recognition; dendrite self-avoidance; homophilic cell adhesion via plasma membrane adhesion molecules
Disease: Gaze Palsy, Familial Horizontal, With Progressive Scoliosis
Reference #:  Q96MS0 (UniProtKB)
Alt. Names/Synonyms: FLJ21044; HGPPS; HGPPS1; HGPS; RBIG1; retinoblastoma inhibiting gene 1; RIG1; ROBO3; roundabout guidance receptor 3; Roundabout homolog 3; roundabout, axon guidance receptor, homolog 3; roundabout, axon guidance receptor, homolog 3 (Drosophila); Roundabout-like protein 3
Gene Symbols: ROBO3
Molecular weight: 148,209 Da
Basal Isoelectric point: 6.74  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene