ABHD17A Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towards MAP6. Belongs to the AB hydrolase superfamily. ABHD17 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.-.-.-; Hydrolase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10 C1|10 39.72 cM
Cellular Component:  anchored component of postsynaptic density membrane; anchored component of postsynaptic recycling endosome membrane; cell junction; cell projection; endosome; endosome membrane; glutamatergic synapse; membrane; plasma membrane; postsynaptic density; postsynaptic membrane; recycling endosome membrane; synapse
Molecular Function:  hydrolase activity; palmitoyl-(protein) hydrolase activity
Biological Process:  negative regulation of protein localization to microtubule; positive regulation of protein localization to endosome; protein depalmitoylation; protein localization to membrane; protein palmitoylation; regulation of postsynapse organization
Reference #:  Q99JW1 (UniProtKB)
Alt. Names/Synonyms: 1700013O15Rik; AB17A; Abhd17a; abhydrolase domain containing 17A; Abhydrolase domain-containing protein 17A; Abhydrolase domain-containing protein FAM108A; Alpha/beta hydrolase domain-containing protein 17A; BC005632; D10Bwg1364e; F108A; Fam10; Fam108a; family with sequence similarity 108, member A; mFLJ00358 protein; MGC11699; MGC90979; protein ABHD17A
Gene Symbols: Abhd17a
Molecular weight: 33,950 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
Select Structure to View Below

ABHD17A

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene