PIN4 Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. Isoform 2 binds to double-stranded DNA. Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily. Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed. 2 human isoforms generated by alternative promoter usage have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 5.2.1.8; Isomerase; Mitochondrial; Nucleolus
Chromosomal Location of mouse Ortholog: X|X D
Cellular Component:  chromosome; cytoplasm; cytoskeleton; mitochondrial matrix; nucleolus; nucleoplasm; nucleus; preribosome; spindle
Molecular Function:  bent DNA binding; DNA binding; double-stranded DNA binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity
Biological Process:  localization; rRNA processing
Reference #:  Q9CWW6 (UniProtKB)
Alt. Names/Synonyms: 2410002I22Rik; EPVH; OTTMUSP00000019885; Par14; Parvulin-14; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; Peptidyl-prolyl cis-trans isomerase Pin4; Pin4; PPIase Pin4; protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin); Rotamase Pin4
Gene Symbols: Pin4
Molecular weight: 13,815 Da
Basal Isoelectric point: 9.78  Predict pI for various phosphorylation states
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PIN4

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein