TLK2 Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Ubiquitous. Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle. Highly expressed in testis. Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); TLK family
Chromosomal Location of Human Ortholog: 17q23.2
Cellular Component:  intermediate filament; nucleus; perinuclear region of cytoplasm
Molecular Function:  ATP binding; protein binding; protein serine/threonine kinase activity
Biological Process:  cell cycle; cellular response to DNA damage stimulus; cellular response to gamma radiation; chromatin organization; chromosome segregation; intracellular signal transduction; negative regulation of autophagy; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; peptidyl-serine phosphorylation; protein phosphorylation; regulation of chromatin assembly or disassembly
Disease: Mental Retardation, Autosomal Dominant 57
Reference #:  Q86UE8 (UniProtKB)
Alt. Names/Synonyms: MGC44450; PKU-alpha; Serine/threonine-protein kinase tousled-like 2; TLK2; Tousled-like kinase 2
Gene Symbols: TLK2
Molecular weight: 87,661 Da
Basal Isoelectric point: 8.65  Predict pI for various phosphorylation states
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TLK2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein