IP3R3 Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Belongs to the InsP3 receptor family. Expressed in intestinal crypt and villus epithelial cells. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 17 A3.3|17 13.68 cM
Cellular Component:  apical part of cell; brush border; cytoplasm; cytoplasmic vesicle membrane; dendrite; endoplasmic reticulum; endoplasmic reticulum membrane; integral component of endoplasmic reticulum membrane; integral component of membrane; integral component of plasma membrane; membrane; myelin sheath; neuronal cell body; nuclear envelope; nuclear outer membrane; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; presynapse; receptor complex; sarcoplasmic reticulum; secretory granule membrane
Molecular Function:  calcium channel activity; calcium ion binding; calcium-release channel activity; inositol 1,3,4,5 tetrakisphosphate binding; inositol 1,4,5 trisphosphate binding; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; inositol hexakisphosphate binding; ion channel activity; phosphatidylinositol binding; protein binding
Biological Process:  calcium ion transmembrane transport; calcium ion transport; calcium ion transport into cytosol; cellular response to cAMP; G protein-coupled receptor signaling pathway; ion transport; long-term synaptic potentiation; memory; positive regulation of cytosolic calcium ion concentration; protein heterooligomerization; protein homooligomerization; release of sequestered calcium ion into cytosol; response to calcium ion; sensory perception of bitter taste; sensory perception of sweet taste; sensory perception of umami taste; transmembrane transport
Reference #:  P70227 (UniProtKB)
Alt. Names/Synonyms: inositol 1,4,5-triphosphate receptor 3; Inositol 1,4,5-trisphosphate receptor type 3; InsP3R3; IP3 receptor; IP3 receptor isoform 3; IP3R 3; Ip3r3; Itp; Itpr-3; Itpr3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor
Gene Symbols: Itpr3
Molecular weight: 304,275 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene