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IP3R3
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Belongs to the InsP3 receptor family. Expressed in intestinal crypt and villus epithelial cells. Note: This description may include information from UniProtKB.
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| Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of mouse Ortholog: 17 A3.3|17 13.68 cM |
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Cellular Component:
apical part of cell; brush border; cytoplasm; cytoplasmic side of endoplasmic reticulum membrane; dendrite; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; neuronal cell body; nuclear envelope; nuclear outer membrane; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; presynapse; receptor complex; sarcoplasmic reticulum; secretory granule membrane
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Molecular Function:
calcium channel activity; calcium ion binding; calcium-release channel activity; identical protein binding; inositol 1,3,4,5 tetrakisphosphate binding; inositol 1,4,5 trisphosphate binding; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; inositol hexakisphosphate binding; monoatomic ion channel activity; phosphatidylinositol binding; protein binding; protein-containing complex binding
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Biological Process:
calcium ion homeostasis; calcium ion transmembrane transport; calcium ion transport; cellular response to cAMP; G protein-coupled receptor signaling pathway; long-term synaptic potentiation; memory; monoatomic ion transport; positive regulation of cytosolic calcium ion concentration; release of sequestered calcium ion into cytosol; response to calcium ion; sensory perception of bitter taste; sensory perception of sweet taste; sensory perception of umami taste; transmembrane transport
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Reference #:
P70227
(UniProtKB)
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Alt. Names/Synonyms: inositol 1,4,5-triphosphate receptor 3; Inositol 1,4,5-trisphosphate receptor type 3; InsP3R3; IP3 receptor; IP3 receptor isoform 3; IP3R 3; Ip3r3; Itp; Itpr-3; Itpr3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor
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Gene Symbols: Itpr3
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Molecular weight:
304,275 Da
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Basal Isoelectric point:
6.11
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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