USP51 Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin. Belongs to the peptidase C19 family. Expressed in prostate, brain, lung, aorta and kidney. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: Xp11.21
Cellular Component:  chromosome
Molecular Function:  chromatin binding; histone binding; thiol-dependent ubiquitin-specific protease activity; zinc ion binding
Biological Process:  DNA repair; histone deubiquitination; protein deubiquitination; regulation of cell cycle process; regulation of double-strand break repair via homologous recombination; regulation of double-strand break repair via nonhomologous end joining; regulation of response to DNA damage stimulus; ubiquitin-dependent protein catabolic process
Reference #:  Q70EK9 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme 51; Ubiquitin carboxyl-terminal hydrolase 51; ubiquitin specific peptidase 51; ubiquitin specific protease 51; Ubiquitin thioesterase 51; ubiquitin thiolesterase 51; ubiquitin-specific processing protease 51; Ubiquitin-specific-processing protease 51; UBP51; USP51
Gene Symbols: USP51
Molecular weight: 79,756 Da
Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene