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USP51
Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin. Belongs to the peptidase C19 family. Expressed in prostate, brain, lung, aorta and kidney. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease |
| Chromosomal Location of human Ortholog: Xp11.21 |
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Cellular Component:
chromosome
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Molecular Function:
chromatin binding; cysteine-type deubiquitinase activity; histone binding; histone H2A deubiquitinase activity; zinc ion binding
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Biological Process:
chromatin remodeling; DNA damage response; DNA repair; protein deubiquitination; regulation of cell cycle process; regulation of double-strand break repair via homologous recombination; regulation of double-strand break repair via nonhomologous end joining; ubiquitin-dependent protein catabolic process
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Reference #:
Q70EK9
(UniProtKB)
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Alt. Names/Synonyms: Deubiquitinating enzyme 51; Ubiquitin carboxyl-terminal hydrolase 51; ubiquitin specific peptidase 51; ubiquitin specific protease 51; Ubiquitin thioesterase 51; ubiquitin thiolesterase 51; ubiquitin-specific processing protease 51; Ubiquitin-specific-processing protease 51; UBP51; USP51
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Gene Symbols: USP51
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Molecular weight:
79,756 Da
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Basal Isoelectric point:
8.73
Predict pI for various phosphorylation states
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