|
TLK1
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); TLK family |
| Chromosomal Location of human Ortholog: 2q31.1 |
|
Cellular Component:
nucleoplasm; nucleus
|
|
Molecular Function:
ATP binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
|
|
Biological Process:
chromatin organization; chromosome segregation; DNA damage response; intracellular protein transport; intracellular signal transduction; peptidyl-serine phosphorylation; protein phosphorylation; regulation of chromatin organization
|
|
Reference #:
Q9UKI8
(UniProtKB)
|
|
Alt. Names/Synonyms: KIAA0137; PKU-beta; serine threonine protein kinase; Serine/threonine-protein kinase tousled-like 1; SNARE protein kinase SNAK; TLK1; tousled like kinase 1; Tousled-like kinase 1
|
|
Gene Symbols: TLK1
|
|
Molecular weight:
86,700 Da
|
|
Basal Isoelectric point:
8.88
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
