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TLK1
a protein kinase of the TLK family. Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Cell-cycle regulated, maximal activity in S-phase. Inactivated by phosphorylation, possibly by CHK1. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); TLK family |
| Chromosomal Location of Human Ortholog: 2q31.1 |
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Cellular Component:
nucleus
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Molecular Function:
ATP binding; protein binding; protein serine/threonine kinase activity
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Biological Process:
cell cycle; cellular response to DNA damage stimulus; chromatin organization; intracellular protein transport; intracellular signal transduction; protein phosphorylation; regulation of chromatin assembly or disassembly
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Reference #:
Q9UKI8
(UniProtKB)
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Alt. Names/Synonyms: KIAA0137; PKU-beta; serine threonine protein kinase; Serine/threonine-protein kinase tousled-like 1; SNARE protein kinase SNAK; TLK1; Tousled-like kinase 1
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Gene Symbols: TLK1
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Molecular weight:
86,700 Da
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Basal Isoelectric point:
8.88
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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