Kv7.1 Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon. Associates with KCNE beta subunits that modulates current kinetics. Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current. Promotes also a delayed voltage activated potassium current showing outward rectification characteristic. During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current. When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions. This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents. During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion. Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion. When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current. When associated with KCNE4, inhibits voltage-gated potassium channel activity. When associated with KCNE5, this complex only conducts current upon strong and continued depolarization. Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity. Binds with phosphatidylinositol 4,5-bisphosphate. Isoform 2: Non-functional alone but modulatory when coexpressed with the full-length isoform 1. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily. Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7 F5|7 88.12 cM
Cellular Component:  basolateral plasma membrane; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; early endosome; endoplasmic reticulum; endosome; integral component of membrane; integral component of plasma membrane; ion channel complex; late endosome; lysosome; membrane; membrane raft; plasma membrane; sarcolemma; voltage-gated potassium channel complex; zymogen granule membrane
Molecular Function:  calmodulin binding; delayed rectifier potassium channel activity; ion channel activity; ion channel binding; outward rectifier potassium channel activity; phosphatidylinositol-4,5-bisphosphate binding; potassium channel activity; protein homodimerization activity; protein kinase A catalytic subunit binding; protein kinase A regulatory subunit binding; protein phosphatase 1 binding; scaffold protein binding; voltage-gated ion channel activity; voltage-gated potassium channel activity; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Biological Process:  atrial cardiac muscle cell action potential; cardiac muscle contraction; cardiovascular system development; cellular response to cAMP; cellular response to drug; gene silencing; inner ear development; intestinal absorption; ion transport; membrane repolarization; membrane repolarization during action potential; membrane repolarization during atrial cardiac muscle cell action potential; membrane repolarization during cardiac muscle cell action potential; membrane repolarization during ventricular cardiac muscle cell action potential; negative regulation of delayed rectifier potassium channel activity; negative regulation of insulin secretion; negative regulation of voltage-gated potassium channel activity; positive regulation of cardiac muscle contraction; positive regulation of gastric acid secretion; positive regulation of heart rate; positive regulation of potassium ion transmembrane transport; potassium ion export across plasma membrane; potassium ion transmembrane transport; potassium ion transport; regulation of atrial cardiac muscle cell membrane repolarization; regulation of gastric acid secretion; regulation of gene expression by genetic imprinting; regulation of heart rate by cardiac conduction; regulation of ion transmembrane transport; regulation of membrane potential; regulation of membrane repolarization; regulation of ventricular cardiac muscle cell membrane repolarization; renal absorption; response to anesthetic; transmembrane transport; ventricular cardiac muscle cell action potential
Reference #:  P97414 (UniProtKB)
Alt. Names/Synonyms: AW559127; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; Kcn; Kcna9; Kcnq1; KQT-like 1; Kv7.1; KVLQ; Kvlqt1; Potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel, subfamily Q, member 1; Voltage-gated potassium channel subunit Kv7.1
Gene Symbols: Kcnq1
Molecular weight: 74,514 Da
Basal Isoelectric point: 9.8  Predict pI for various phosphorylation states
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Kv7.1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene