TREK-1
Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1. Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Biological Process: cardiac ventricle development; cellular response to hypoxia; cochlea development; G protein-coupled receptor signaling pathway; memory; negative regulation of cardiac muscle cell proliferation; negative regulation of DNA biosynthetic process; positive regulation of cellular response to hypoxia; potassium ion transmembrane transport; response to axon injury; response to mechanical stimulus; stabilization of membrane potential