TREK-1 Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1. Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 1q41
Cellular Component:  apical plasma membrane; astrocyte projection; calyx of Held; cell surface; endoplasmic reticulum membrane; neuronal cell body; plasma membrane; voltage-gated potassium channel complex
Molecular Function:  outward rectifier potassium channel activity; potassium ion leak channel activity
Biological Process:  cardiac ventricle development; cellular response to hypoxia; cochlea development; G protein-coupled receptor signaling pathway; memory; negative regulation of cardiac muscle cell proliferation; negative regulation of DNA biosynthetic process; positive regulation of cellular response to hypoxia; potassium ion transmembrane transport; response to axon injury; response to mechanical stimulus; stabilization of membrane potential
Reference #:  O95069 (UniProtKB)
Alt. Names/Synonyms: hTREK-1c; hTREK-1e; K2p2.1; K2P2.1 potassium channel; KCNK2; MGC126742; MGC126744; Outward rectifying potassium channel protein TREK-1; Potassium channel subfamily K member 2; potassium channel subfamily k member 2 variant 1; potassium channel subfamily k member 2 variant 2; potassium channel, subfamily K, member 2; potassium channel, two pore domain subfamily K, member 2; potassium inwardly-rectifying channel, subfamily K, member 2; potassium two pore domain channel subfamily K member 2; tandem-pore-domain potassium channel TREK-1; TPKC1; TREK; TREK-1; TREK-1 K(+) channel subunit; TREK1; TWIK-related potassium channel 1; Two pore domain potassium channel TREK-1; Two pore potassium channel TPKC1; two-pore potassium channel 1
Gene Symbols: KCNK2
Molecular weight: 47,093 Da
Basal Isoelectric point: 8.46  Predict pI for various phosphorylation states
Select Structure to View Below

TREK-1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein