TREK-1 Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1. Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1|1 H6
Cellular Component:  apical plasma membrane; astrocyte projection; axon; axon terminus; calyx of Held; cell surface; endoplasmic reticulum; integral component of membrane; integral component of plasma membrane; membrane; neuron projection; neuronal cell body; nucleus; plasma membrane; voltage-gated potassium channel complex
Molecular Function:  outward rectifier potassium channel activity; potassium channel activity; potassium channel inhibitor activity; potassium ion leak channel activity; protein binding; voltage-gated potassium channel activity
Biological Process:  G protein-coupled receptor signaling pathway; ion transport; negative regulation of cardiac muscle cell proliferation; negative regulation of DNA biosynthetic process; positive regulation of cell death; positive regulation of cellular response to hypoxia; potassium ion transmembrane transport; potassium ion transport; regulation of membrane potential; stabilization of membrane potential
Reference #:  P97438 (UniProtKB)
Alt. Names/Synonyms: A430027H14Rik; AI848635; Kcnk2; Outward rectifying potassium channel protein TREK-1; Potassium channel subfamily K member 2; potassium channel, subfamily K, member 2; TREK-; TREK-1; TREK-1 K(+) channel subunit; Two pore potassium channel TPKC1
Gene Symbols: Kcnk2
Molecular weight: 46,844 Da
Basal Isoelectric point: 8.16  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene