TMSB4X Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase. Belongs to the thymosin beta family. Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: X F5|X 78.28 cM
Cellular Component:  cytoplasm; cytoskeleton; cytosol; nucleus
Molecular Function:  actin binding; actin monomer binding; protein binding
Biological Process:  actin filament organization; positive regulation of smooth muscle cell differentiation; positive regulation of smooth muscle cell migration; positive regulation of transcription, DNA-templated; regulation of cell migration; sequestering of actin monomers
Reference #:  P20065 (UniProtKB)
Alt. Names/Synonyms: Hematopoietic system regulatory peptide; OTTMUSP00000021122; prothymosin beta 4; Ptmb; Ptmb4; Seraspenide; T beta 4; Tb4; Tbeta; Tbeta4; Thymosin beta-4; thymosin, beta 4, X chromosome; Tmsb4; Tmsb4x; TYB4
Gene Symbols: Tmsb4x
Molecular weight: 5,679 Da
Basal Isoelectric point: 5.02  Predict pI for various phosphorylation states
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TMSB4X

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene