TESK2
Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 2.7.12.1; Kinase, protein; LISK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Protein kinase, dual-specificity (non-receptor); TESK subfamily; TKL group |
Chromosomal Location of human Ortholog: 1p34.1 |
Cellular Component:
cytoplasm; nuclear body; nucleoplasm; nucleus
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Molecular Function:
ATP binding; metal ion binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity
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Biological Process:
actin cytoskeleton organization; focal adhesion assembly; protein phosphorylation; spermatogenesis
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Reference #:
Q96S53
(UniProtKB)
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Alt. Names/Synonyms: Dual specificity testis-specific protein kinase 2; TESK2; Testicular protein kinase 2; testis associated actin remodelling kinase 2; testis-specific kinase 2
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Gene Symbols: TESK2
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Molecular weight:
63,639 Da
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Basal Isoelectric point:
6.63
Predict pI for various phosphorylation states
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CST Pathways:
Microtubule Dynamics
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