TESK2 Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; LISK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Protein kinase, dual-specificity (non-receptor); TESK subfamily; TKL group
Chromosomal Location of human Ortholog: 1p34.1
Cellular Component:  nuclear body; nucleoplasm; nucleus
Molecular Function:  ATP binding; metal ion binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity
Biological Process:  actin cytoskeleton organization; focal adhesion assembly; peptidyl-tyrosine phosphorylation; protein phosphorylation; spermatogenesis
Reference #:  Q96S53 (UniProtKB)
Alt. Names/Synonyms: Dual specificity testis-specific protein kinase 2; TESK2; Testicular protein kinase 2; testis associated actin remodelling kinase 2; testis-specific kinase 2
Gene Symbols: TESK2
Molecular weight: 63,639 Da
Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene