DLG7 a cell cycle regulator that may play a role in carcinogenesis. Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells. Required for chromosome congression and alignment. Stabilizes mitotic microtubules, promotes microtubule polymerization and controls spindle formation and dynamics Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Interacts with CDC2 and localizes to the spindle poles in mitotic cells. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDC2/Cyclin B-phosphorylation dependent manner. Colocalizes with E-cadherin (CDH1) at sites of cell-cell contact in intestinal epithelial cells. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Microtubule-binding
Chromosomal Location of Human Ortholog: 14 C1|14 24.6 cM
Cellular Component:  cytoplasm; cytoskeleton; cytosol; microtubule organizing center; mitochondrion; nucleus; spindle pole centrosome
Molecular Function:  phosphoprotein phosphatase activity
Biological Process:  cell cycle; signaling
Reference #:  Q8K4R9 (UniProtKB)
Alt. Names/Synonyms: C77459; C86398; DAP-5; Discs large homolog 7; discs, large (Drosophila) homolog-associated protein 5; discs, large homolog 7; discs, large homolog-associated protein 5; Disks large-associated protein 5; Disks large-associated protein DLG7; Dlg7; Dlgap5; DLGP5; Hepatoma up-regulated protein homolog; HURP; Kiaa0008; mKIAA0008
Gene Symbols: Dlgap5
Molecular weight: 90,196 Da
Basal Isoelectric point: 9.28  Predict pI for various phosphorylation states
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DLG7

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene