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DLG7
Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. Belongs to the SAPAP family. Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Microtubule-binding |
| Chromosomal Location of mouse Ortholog: 14 C1|14 24.6 cM |
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Cellular Component:
cytoplasm; cytoskeleton; cytosol; mitotic spindle; nucleus; spindle pole centrosome
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Molecular Function:
microtubule binding
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Biological Process:
cell cycle; centrosome localization; chromosome segregation; kinetochore assembly; mitotic spindle organization; regulation of mitotic cell cycle; signaling
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Reference #:
Q8K4R9
(UniProtKB)
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Alt. Names/Synonyms: C77459; C86398; DAP-5; Discs large homolog 7; discs, large (Drosophila) homolog-associated protein 5; discs, large homolog 7; discs, large homolog-associated protein 5; Disks large-associated protein 5; Disks large-associated protein DLG7; Dlg; DLG associated protein 5; Dlg7; Dlgap5; DLGP5; Hepatoma up-regulated protein homolog; HURP; Kiaa0008; mKIAA0008
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Gene Symbols: Dlgap5
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Molecular weight:
90,196 Da
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Basal Isoelectric point:
9.28
Predict pI for various phosphorylation states
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