TESK1 Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; LISK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TESK subfamily; TKL group
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component:  cytosol
Molecular Function:  ATP binding; metal ion binding; protein binding; protein C-terminus binding; protein kinase binding; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity
Biological Process:  negative regulation of protein autophosphorylation; negative regulation of protein serine/threonine kinase activity; peptidyl-tyrosine phosphorylation; positive regulation of stress fiber assembly; regulation of protein localization; spermatogenesis
Reference #:  Q15569 (UniProtKB)
Alt. Names/Synonyms: Dual specificity testis-specific protein kinase 1; TESK1; Testicular protein kinase 1; testis associated actin remodelling kinase 1; testis-specific kinase 1
Gene Symbols: TESK1
Molecular weight: 67,684 Da
Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene