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TPM4
a cytoskeletal protein that binds to actin filaments in muscle and nonmuscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments and endocytosis. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 19p13.12-p13.11 |
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Cellular Component:
cortical cytoskeleton; cytoskeleton; cytosol; muscle thin filament tropomyosin; podosome; stress fiber
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Molecular Function:
actin filament binding; calcium ion binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; structural constituent of muscle
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Biological Process:
muscle contraction; muscle filament sliding
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Reference #:
P67936
(UniProtKB)
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Alt. Names/Synonyms: TM30p1; TPM4; tropomyosin 4; Tropomyosin alpha-4 chain; Tropomyosin-4
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Gene Symbols: TPM4
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Molecular weight:
28,522 Da
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Basal Isoelectric point:
4.67
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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