TPM4 a cytoskeletal protein that binds to actin filaments in muscle and nonmuscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments and endocytosis. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19p13.12-p13.11
Cellular Component:  cortical cytoskeleton; cytoskeleton; cytosol; muscle thin filament tropomyosin; podosome; stress fiber
Molecular Function:  actin filament binding; calcium ion binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; structural constituent of muscle
Biological Process:  muscle contraction; muscle filament sliding
Reference #:  P67936 (UniProtKB)
Alt. Names/Synonyms: TM30p1; TPM4; tropomyosin 4; Tropomyosin alpha-4 chain; Tropomyosin-4
Gene Symbols: TPM4
Molecular weight: 28,522 Da
Basal Isoelectric point: 4.67  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein