TPM4 Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. Belongs to the tropomyosin family. Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level). 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19p13.12-p13.11
Cellular Component:  cortical cytoskeleton; cytoskeleton; cytosol; muscle thin filament tropomyosin; podosome; stress fiber
Molecular Function:  actin filament binding; calcium ion binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; structural constituent of muscle
Biological Process:  muscle contraction; muscle filament sliding
Reference #:  P67936 (UniProtKB)
Alt. Names/Synonyms: TM30p1; TPM4; tropomyosin 4; Tropomyosin alpha-4 chain; Tropomyosin-4
Gene Symbols: TPM4
Molecular weight: 28,522 Da
Basal Isoelectric point: 4.67  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below

TPM4

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein