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APOBEC3D
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons. Belongs to the cytidine and deoxycytidylate deaminase family. Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.5.4.-; Hydrolase |
| Chromosomal Location of human Ortholog: 22q13.1 |
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Cellular Component:
cytoplasm; nucleus; P-body
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Molecular Function:
cytidine deaminase activity; deoxycytidine deaminase activity; RNA binding; zinc ion binding
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Biological Process:
clearance of foreign intracellular DNA; cytidine deamination; cytidine to uridine editing; defense response to virus; DNA cytosine deamination; DNA demethylation; innate immune response; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
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Reference #:
Q96AK3
(UniProtKB)
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Alt. Names/Synonyms: A3D; A3DE; ABC3D; APOBEC3D; APOBEC3DE; APOBEC3E; apolipoprotein B mRNA editing enzyme catalytic subunit 3D; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3E pseudogene; ARP6; DNA dC->dU-editing enzyme APOBEC-3D; Probable DNA dC->dU-editing enzyme APOBEC-3D
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Gene Symbols: APOBEC3D
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Molecular weight:
46,598 Da
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Basal Isoelectric point:
8.73
Predict pI for various phosphorylation states
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