CYP2A6 Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity. Belongs to the cytochrome P450 family. Liver. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - retinol; EC; Endoplasmic reticulum; Oxidoreductase; Secondary Metabolites Metabolism - caffeine; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes
Chromosomal Location of human Ortholog: 19q13.2
Cellular Component:  cytoplasm; cytoplasmic microtubule; endoplasmic reticulum membrane; intracellular membrane-bounded organelle
Molecular Function:  arachidonic acid epoxygenase activity; coumarin 7-hydroxylase activity; enzyme binding; heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; steroid hydroxylase activity
Biological Process:  coumarin catabolic process; coumarin metabolic process; epoxygenase P450 pathway; organic acid metabolic process; steroid metabolic process; xenobiotic catabolic process; xenobiotic metabolic process
Disease: Coumarin Resistance; Lung Cancer; Tobacco Addiction, Susceptibility To
Reference #:  P11509 (UniProtKB)
Alt. Names/Synonyms: 1,4-cineole 2-exo-monooxygenase; Coumarin 7-hydroxylase; CP2A6; CPA6; CYP2A; CYP2A3; CYP2A6; CYPIIA6; Cytochrome P450 2A6; cytochrome P450 family 2 subfamily A member 6; Cytochrome P450 IIA3; Cytochrome P450(I); cytochrome P450, family 2, subfamily A, polypeptide 6; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6; flavoprotein-linked monooxygenase; P450C2A; P450PB; xenobiotic monooxygenase
Gene Symbols: CYP2A6
Molecular weight: 56,517 Da
Basal Isoelectric point: 9.24  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein