KOR-3
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. Belongs to the G-protein coupled receptor 1 family. Detected in blood leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
Chromosomal Location of rat Ortholog: 3q43 |
Cellular Component:
cytoplasmic vesicle; neuron projection; plasma membrane
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Molecular Function:
G protein-coupled receptor activity; neuropeptide binding; nociceptin receptor activity; protein binding
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Biological Process:
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; conditioned place preference; eating behavior; estrous cycle; G protein-coupled opioid receptor signaling pathway; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of blood pressure; negative regulation of cAMP-mediated signaling; negative regulation of voltage-gated calcium channel activity; neuropeptide signaling pathway; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of urine volume; regulation of locomotor rhythm; response to estradiol; sensory perception of pain
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Reference #:
P35370
(UniProtKB)
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Alt. Names/Synonyms: Kappa-type 3 opioid receptor; KOR-3; KOR3; LC132; MOR-C; Nociceptin receptor; nociceptin receptor ORL1; OFQR; Oor; opiate receptor-like 1; opioid receptor-like 1; Oprl; Oprl1; OPRX; ORL1; Orphanin FQ receptor; orphanin FQ receptor-a; orphanin FQ receptor-b; orphanin FQ receptor-e; peptide receptor; ROR-C; seven transmembrane G protein-coupled receptor; XOR1
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Gene Symbols: Oprl1
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Molecular weight:
40,523 Da
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Basal Isoelectric point:
8.5
Predict pI for various phosphorylation states
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