ARPC2 Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Belongs to the ARPC2 family. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 2q35
Cellular Component:  actin cytoskeleton; Arp2/3 protein complex; cytosol; endosome; glutamatergic synapse; lamellipodium; muscle cell projection membrane; neuron projection; nucleus; site of double-strand break
Molecular Function:  protein binding; structural constituent of cytoskeleton
Biological Process:  actin filament polymerization; actin polymerization-dependent cell motility; Arp2/3 complex-mediated actin nucleation; ephrin receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; membrane organization; positive regulation of lamellipodium assembly; positive regulation of substrate adhesion-dependent cell spreading
Reference #:  O15144 (UniProtKB)
Alt. Names/Synonyms: actin related protein 2/3 complex subunit 2; actin related protein 2/3 complex, subunit 2, 34kDa; Actin-related protein 2/3 complex subunit 2; ARC34; Arp2/3 complex 34 kDa subunit; ARP2/3 protein complex subunit 34; ARPC2; p34-ARC; PNAS-139; PRO2446; testis tissue sperm-binding protein Li 53e
Gene Symbols: ARPC2
Molecular weight: 34,333 Da
Basal Isoelectric point: 6.84  Predict pI for various phosphorylation states
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ARPC2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein