SCN1B Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of multiple pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. Isoform 2: Cell adhesion molecule that plays a critical role in neuronal migration and pathfinding during brain development. Stimulates neurite outgrowth. Has no regulatory function on the SCN2A sodium channel complex. Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family. The overall expression of isoform 1 and isoform 2 is very similar. Isoform 1 is abundantly expressed in skeletal muscle, heart and brain. Isoform 2 is highly expressed in brain and skeletal muscle and present at a very low level in heart, placenta, lung, liver, kidney and pancreas. In brain, isoform 2 is most abundant in the cerebellum, followed by the cerebral cortex and occipital lobe, while isoform 1 levels are higher in the cortex compared to the cerebellum. Isoform 2 is expressed in many regions of the brain, including cerebellar Purkinje cells, cortex pyramidal neurons and many of the neuronal fibers throughout the brain (at protein level). Also detected in dorsal root ganglion, in fibers of the spinal nerve and in cortical neurons and their processes (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, sodium; Membrane protein, integral
Chromosomal Location of mouse Ortholog: 7 B1|7 19.3 cM
Cellular Component:  cell projection; intercalated disc; membrane; node of Ranvier; plasma membrane; sodium channel complex; T-tubule; voltage-gated sodium channel complex
Molecular Function:  protein binding; sodium channel activity; sodium channel inhibitor activity; sodium channel regulator activity; transmembrane transporter binding; voltage-gated monoatomic ion channel activity; voltage-gated sodium channel activity; voltage-gated sodium channel activity involved in cardiac muscle cell action potential; voltage-gated sodium channel activity involved in Purkinje myocyte action potential
Biological Process:  axon guidance; cardiac conduction; cardiac muscle cell action potential involved in contraction; cardiac muscle contraction; corticospinal neuron axon guidance; locomotion; membrane depolarization; membrane depolarization during cardiac muscle cell action potential; membrane depolarization during Purkinje myocyte cell action potential; monoatomic ion transport; neuron projection development; neuronal action potential propagation; positive regulation of neuron projection development; positive regulation of sodium ion transport; regulation of atrial cardiac muscle cell membrane depolarization; regulation of heart rate by cardiac conduction; regulation of monoatomic ion transmembrane transport; regulation of sodium ion transmembrane transporter activity; regulation of sodium ion transport; regulation of ventricular cardiac muscle cell membrane repolarization; regulation of voltage-gated sodium channel activity; response to pyrethroid; sodium ion transmembrane transport; sodium ion transport
Reference #:  P97952 (UniProtKB)
Alt. Names/Synonyms: Scn1b; Sodium channel subunit beta-1; sodium channel, voltage-gated, type I, beta; sodium channel, voltage-gated, type I, beta polypeptide
Gene Symbols: Scn1b
Molecular weight: 24,650 Da
Basal Isoelectric point: 4.8  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SCN1B

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein