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CXCL1
Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. Belongs to the intercrine alpha (chemokine CxC) family. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 4q13.3 |
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Cellular Component:
extracellular region; extracellular space; specific granule lumen; tertiary granule lumen
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Molecular Function:
chemokine activity; CXCR chemokine receptor binding; enzyme activator activity; growth factor activity; protein binding; signaling receptor binding
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Biological Process:
actin cytoskeleton organization; antimicrobial humoral immune response mediated by antimicrobial peptide; cellular response to lipopolysaccharide; chemokine-mediated signaling pathway; chemotaxis; G protein-coupled receptor signaling pathway; inflammatory response; intracellular signal transduction; negative regulation of cell population proliferation; nervous system development; neutrophil chemotaxis; signal transduction
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Reference #:
P09341
(UniProtKB)
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Alt. Names/Synonyms: C-X-C motif chemokine 1; C-X-C motif chemokine ligand 1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); CXCL1; fibroblast secretory protein; FSP; GRO; GRO-alpha(1-73); GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73); GRO1; GRO1 oncogene (melanoma growth stimulating activity, alpha); GRO1 oncogene (melanoma growth-stimulating activity); GROA; Growth-regulated alpha protein; melanoma growth stimulating activity, alpha; Melanoma growth stimulatory activity; melanoma growth stimulatory activity alpha; MGSA; MGSA alpha; MGSA-a; NAP-3; Neutrophil-activating protein 3; SCYB1
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Gene Symbols: CXCL1
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Molecular weight:
11,301 Da
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Basal Isoelectric point:
10.46
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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