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14-3-3 theta
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. Belongs to the 14-3-3 family. Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of Human Ortholog: 12|12 A1.3 |
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Cellular Component:
cytoplasm; protein-containing complex; synapse
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Molecular Function:
14-3-3 protein binding; identical protein binding; ion channel binding; protein binding; protein C-terminus binding; protein domain specific binding; protein N-terminus binding
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Biological Process:
negative regulation of ion transmembrane transport; negative regulation of transcription, DNA-templated; protein targeting; signal transduction; small GTPase mediated signal transduction
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Reference #:
P68254
(UniProtKB)
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Alt. Names/Synonyms: 14-3-3 protein tau; 14-3-3 protein theta; 14-3-3 tau; 14-3-3 theta; 1433T; 2700028P07Rik; AA409740; AU021156; MGC118161; OTTMUSP00000017541; R74690; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; Ywhaq
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Gene Symbols: Ywhaq
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Molecular weight:
27,778 Da
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Basal Isoelectric point:
4.69
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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G2/M DNA Damage Checkpoint
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Growth And Differentiation Control by MAPKs
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Hippo Signaling
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Mitochondrial Control of Apoptosis
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PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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