KLF12 Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. Belongs to the Sp1 C2H2-type zinc-finger protein family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q21
Cellular Component:  cytosol; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; nucleic acid binding; RNA polymerase II regulatory region sequence-specific DNA binding
Biological Process:  negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  D3ZG44 (UniProtKB)
Alt. Names/Synonyms: Klf12; Kruppel-like factor 12
Gene Symbols: Klf12
Molecular weight: 45,054 Da
Basal Isoelectric point: 9.38  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein