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KLF12
Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. Belongs to the Sp1 C2H2-type zinc-finger protein family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; DNA-binding; Membrane protein, integral |
| Chromosomal Location of Human Ortholog: 15q21 |
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Cellular Component:
cytosol; nucleoplasm; nucleus
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Molecular Function:
DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; nucleic acid binding; RNA polymerase II regulatory region sequence-specific DNA binding
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Biological Process:
negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
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Reference #:
D3ZG44
(UniProtKB)
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Alt. Names/Synonyms: Klf12; Kruppel-like factor 12
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Gene Symbols: Klf12
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Molecular weight:
45,054 Da
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Basal Isoelectric point:
9.38
Predict pI for various phosphorylation states
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