HOXA10 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'. Belongs to the Abd-B homeobox family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of mouse Ortholog: 6 B3|6 25.4 cM
Cellular Component:  cytoplasm; nucleoplasm; nucleus; transcription regulator complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; histone deacetylase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding
Biological Process:  anterior/posterior pattern specification; embryonic limb morphogenesis; male gonad development; multicellular organism development; positive regulation of transcription by RNA polymerase II; proximal/distal pattern formation; regulation of DNA-templated transcription; regulation of gene expression; regulation of transcription by RNA polymerase II; single fertilization; skeletal system development; spermatogenesis; uterus development
Reference #:  P31310 (UniProtKB)
Alt. Names/Synonyms: homeo box A10; homeobox A10; Homeobox protein Hox-1.8; Homeobox protein Hox-A10; Hox-1.; Hox-1.8; Hoxa-; Hoxa-10; Hoxa10; HXA10; OTTMUSP00000020429
Gene Symbols: Hoxa10
Molecular weight: 43,292 Da
Basal Isoelectric point: 8.48  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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HOXA10

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene