HOXA10
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'. Belongs to the Abd-B homeobox family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: DNA-binding; Transcription factor |
Chromosomal Location of mouse Ortholog: 6 B3|6 25.4 cM |
Cellular Component:
cytoplasm; nucleoplasm; nucleus; transcription regulator complex
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; histone deacetylase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
anterior/posterior pattern specification; embryonic limb morphogenesis; male gonad development; multicellular organism development; positive regulation of transcription by RNA polymerase II; proximal/distal pattern formation; regulation of DNA-templated transcription; regulation of gene expression; regulation of transcription by RNA polymerase II; single fertilization; skeletal system development; spermatogenesis; uterus development
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Reference #:
P31310
(UniProtKB)
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Alt. Names/Synonyms: homeo box A10; homeobox A10; Homeobox protein Hox-1.8; Homeobox protein Hox-A10; Hox-1.; Hox-1.8; Hoxa-; Hoxa-10; Hoxa10; HXA10; OTTMUSP00000020429
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Gene Symbols: Hoxa10
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Molecular weight:
43,292 Da
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Basal Isoelectric point:
8.48
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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