GGA1 Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane. Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network. Belongs to the GGA protein family. Ubiquitously expressed. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Vesicle
Chromosomal Location of Human Ortholog: 15|15 E1
Cellular Component:  early endosome; endosome; Golgi apparatus; intracellular membrane-bounded organelle; membrane; nucleoplasm; protein-containing complex
Molecular Function:  ADP-ribosylation factor binding; protein binding; protein heterodimerization activity
Biological Process:  Golgi to plasma membrane protein transport; Golgi to plasma membrane transport; intracellular protein transport; positive regulation of protein catabolic process; protein localization; protein localization to cell surface; protein localization to ciliary membrane; protein transport; retrograde transport, endosome to Golgi; toxin transport; vesicle-mediated transport
Reference #:  Q8R0H9 (UniProtKB)
Alt. Names/Synonyms: 4930406E12Rik; ADP-ribosylation factor-binding protein GGA1; AU016030; AW209092; Gamma-adaptin-related protein 1; Gga1; golgi associated, gamma adaptin ear containing, ARF binding protein 1; Golgi-localized, gamma ear-containing, ARF-binding protein 1
Gene Symbols: Gga1
Molecular weight: 69,972 Da
Basal Isoelectric point: 5.17  Predict pI for various phosphorylation states
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GGA1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene