CD46 Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3. (Microbial infection) Acts as a receptor for cultured Measles virus. (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6. (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes. Expressed by all cells except erythrocytes. 16 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral; Receptor, misc.
Chromosomal Location of mouse Ortholog: 1 H6|1 98.41 cM
Cellular Component:  acrosomal vesicle; basolateral plasma membrane; cell surface; cytoplasm; cytoplasmic vesicle; extracellular region; Golgi apparatus; inner acrosomal membrane; integral component of membrane; membrane; plasma membrane
Molecular Function:  cadherin binding; complement binding
Biological Process:  interleukin-10 production; negative regulation of complement activation; negative regulation of gene expression; positive regulation of gene expression; positive regulation of interleukin-10 production; positive regulation of memory T cell differentiation; positive regulation of regulatory T cell differentiation; positive regulation of T cell proliferation; positive regulation of transforming growth factor beta production; proteolysis; regulation of Notch signaling pathway; sequestering of extracellular ligand from receptor; single fertilization; T cell mediated immunity
Reference #:  O88174 (UniProtKB)
Alt. Names/Synonyms: Cd46; CD46 antigen, complement regulatory protein; Mcp; Membrane cofactor protein
Gene Symbols: Cd46
Molecular weight: 40,882 Da
Basal Isoelectric point: 8.16  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene