ZHX2 Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells. In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex. Belongs to the ZHX family. Ubiquitously expressed. Expressed in podocytes. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 15 D1|15 24.01 cM
Cellular Component:  cytosol; nucleoplasm; nucleus; plasma membrane
Molecular Function:  DNA binding; DNA-binding transcription factor activity; identical protein binding; metal ion binding; nucleic acid binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription corepressor activity
Biological Process:  cell differentiation; mRNA catabolic process; negative regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; nervous system development; regulation of transcription by RNA polymerase II; retinal bipolar neuron differentiation; somatic stem cell population maintenance
Reference #:  Q8C0C0 (UniProtKB)
Alt. Names/Synonyms: AFP regulator 1; Afr-1; Afr1; alpha fetoprotein regulation 1, adult; Alpha-fetoprotein regulator 1; mKIAA0854; Raf; Regulator of AFP; Zhx2; Zinc finger and homeodomain protein 2; zinc fingers and homeoboxes 2; Zinc fingers and homeoboxes protein 2
Gene Symbols: Zhx2
Molecular weight: 92,259 Da
Basal Isoelectric point: 7.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene