TMOD3 Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. Belongs to the tropomodulin family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 9 D|9 42.3 cM
Cellular Component:  cytoplasm; cytoskeleton; filamentous actin; lamellipodium; myofibril; ruffle; striated muscle thin filament
Molecular Function:  actin binding; microtubule minus-end binding; tropomyosin binding
Biological Process:  actin cytoskeleton organization; actin filament organization; erythrocyte development; mitotic cell cycle phase transition; muscle contraction; myofibril assembly; pointed-end actin filament capping; positive regulation of mitotic cell cycle phase transition
Reference #:  Q9JHJ0 (UniProtKB)
Alt. Names/Synonyms: Tmod3; tropomodulin 3; Tropomodulin-3; U-Tmo; U-Tmod; Ubiquitous tropomodulin; UTMO; UTMOD
Gene Symbols: Tmod3
Molecular weight: 39,503 Da
Basal Isoelectric point: 5.02  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below

TMOD3

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein