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SPIRE1
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. Belongs to the spire family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal |
| Chromosomal Location of mouse Ortholog: 18|18 E1 |
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Cellular Component:
cell cortex; cleavage furrow; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytoskeleton; cytosol; Golgi apparatus; membrane; mitochondrial outer membrane; nucleoplasm; plasma membrane
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Molecular Function:
actin binding
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Biological Process:
actin cytoskeleton organization; actin filament network formation; actin filament organization; actin filament polymerization; actin nucleation; behavioral fear response; cleavage furrow formation; dendritic spine development; establishment of meiotic spindle localization; formin-nucleated actin cable assembly; Golgi vesicle transport; intracellular transport; polar body extrusion after meiotic divisions; positive regulation of double-strand break repair; positive regulation of mitochondrial fission; protein transport; vesicle-mediated transport
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Reference #:
Q52KF3
(UniProtKB)
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Alt. Names/Synonyms: 6030430B19Rik; AI415299; AU022898; AW550622; Protein spire homolog 1; Spir-1; SPIR1; spire homolog 1; spire homolog 1 (Drosophila); spire type actin nucleation factor 1; Spire1
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Gene Symbols: Spire1
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Molecular weight:
68,450 Da
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Basal Isoelectric point:
9.2
Predict pI for various phosphorylation states
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