SMARCA5 Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. Ubiquitously expressed. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.1.-; EC 3.6.4.-; Helicase; Histone-binding; Transcription factor
Chromosomal Location of mouse Ortholog: 8|8 C2
Cellular Component:  ACF complex; B-WICH complex; CHRAC; chromatin silencing complex; chromosome; condensed chromosome; fibrillar center; ISWI-type complex; NoRC complex; nuclear replication fork; nucleolus; nucleoplasm; nucleus; NURF complex; pericentric heterochromatin; RSF complex; site of double-strand break; WICH complex
Molecular Function:  ATP binding; ATP hydrolysis activity; ATP-dependent activity, acting on DNA; ATP-dependent chromatin remodeler activity; DNA binding; helicase activity; histone binding; histone octamer slider activity; hydrolase activity; nucleosome binding; nucleotide binding; protein binding
Biological Process:  cellular response to leukemia inhibitory factor; chromatin organization; chromatin remodeling; DNA repair; DNA-templated transcription initiation; embryo development; heterochromatin formation; negative regulation of mitotic chromosome condensation; negative regulation of transcription by RNA polymerase I; nucleosome assembly; positive regulation of DNA replication; positive regulation of DNA-templated transcription; positive regulation of histone acetylation; positive regulation of histone deacetylation; positive regulation of histone methylation; positive regulation of transcription by RNA polymerase I; positive regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase III; rDNA heterochromatin formation; regulation of DNA methylation; regulation of DNA replication; regulation of DNA-templated transcription; regulation of response to DNA damage stimulus
Reference #:  Q91ZW3 (UniProtKB)
Alt. Names/Synonyms: 4933427E24Rik; D030040M08Rik; D330027N15Rik; MommeD; MommeD4; mSnf2h; OTTMUSP00000028263; Smarca5; SMCA5; Snf; Snf2h; Sucrose nonfermenting protein 2 homolog; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
Gene Symbols: Smarca5
Molecular weight: 121,627 Da
Basal Isoelectric point: 8.35  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene