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SH3KBP1
Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit. May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Ubiquitously expressed. Also expressed in some cancer cell lines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Apoptosis; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: X|X F4 |
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Cellular Component:
anchoring junction; cell-cell junction; cytoplasm; cytoplasmic vesicle; cytoskeleton; endocytic vesicle; membrane; neuron projection; synapse
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Molecular Function:
molecular adaptor activity; protein binding; SH3 domain binding; ubiquitin protein ligase binding
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Biological Process:
actin filament organization; apoptotic process; cell migration; cytoskeleton organization; endocytosis; positive regulation of B cell activation; regulation of cell shape; ubiquitin-dependent endocytosis
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Reference #:
Q8R550
(UniProtKB)
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Alt. Names/Synonyms: 1200007H22Rik; 1700125L08Rik; 5830464D22Rik; AI447724; Cin85; IN85; OTTMUSP00000020961; Regulator of ubiquitous kinase; Ruk; Ruk(deltaA) protein; Ruk(h) protein; Ruk(l) protein; Ruk(m1) protein; Ruk(m3) protein; Ruk(t) protein; Ruk(xl) protein; Seta; Sh3 containing, expressed in astrocytes; SH3 domain-containing kinase-binding protein 1; SH3-containing, expressed in tumorigenic astrocytes; SH3-domain kinase binding protein 1; SH3K1; Sh3kbp1
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Gene Symbols: Sh3kbp1
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Molecular weight:
78,170 Da
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Basal Isoelectric point:
7.15
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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