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MST2
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1. Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Expressed at high levels in adult kidney, skeletal and placenta tissues and at very low levels in adult heart, lung and brain tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Autophagy; EC 2.7.11.1; Kinase, protein; MST subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family |
| Chromosomal Location of human Ortholog: 8q22.2 |
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Cellular Component:
cytoplasm; cytosol; nucleus; protein-containing complex
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Molecular Function:
ATP binding; identical protein binding; magnesium ion binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity
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Biological Process:
apoptotic process; canonical Wnt signaling pathway; cell differentiation involved in embryonic placenta development; central nervous system development; endocardium development; epithelial cell proliferation; extrinsic apoptotic signaling pathway via death domain receptors; hepatocyte apoptotic process; hippo signaling; intracellular signal transduction; JNK cascade; negative regulation of canonical Wnt signaling pathway; negative regulation of epithelial cell proliferation; negative regulation of organ growth; neural tube formation; organ growth; positive regulation of apoptotic process; positive regulation of DNA-binding transcription factor activity; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of fat cell differentiation; positive regulation of JNK cascade; positive regulation of protein binding; positive regulation of protein kinase B signaling; primitive hemopoiesis; protein import into nucleus; protein kinase B signaling; protein phosphorylation; protein stabilization; protein tetramerization; regulation of cell differentiation involved in embryonic placenta development; regulation of MAPK cascade; selective autophagy; signal transduction
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Reference #:
Q13188
(UniProtKB)
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Alt. Names/Synonyms: epididymis secretory sperm binding protein; FLJ90748; hippo homolog; KB-1458E12.1; KRS1; Mammalian STE20-like protein kinase 2; MST-2; MST2; MST2/C; MST2/N; serine/threonine kinase 3; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); Serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 20kDa subunit; Serine/threonine-protein kinase 3 36kDa subunit; Serine/threonine-protein kinase Krs-1; STE20-like kinase MST2; STK3
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Gene Symbols: STK3
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Molecular weight:
56,301 Da
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Basal Isoelectric point:
5.12
Predict pI for various phosphorylation states
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CST Pathways:
Hippo Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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