LEDGF Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. Belongs to the HDGF family. Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 4|4 C3
Cellular Component:  nuclear heterochromatin; nuclear periphery; nucleoplasm; nucleus; transcriptionally active chromatin
Molecular Function:  activating transcription factor binding; chromatin binding; DNA binding; supercoiled DNA binding; transcription coactivator activity
Biological Process:  mRNA 5'-splice site recognition; positive regulation of transcription by RNA polymerase II; response to heat; response to oxidative stress
Reference #:  Q99JF8 (UniProtKB)
Alt. Names/Synonyms: AA408851; AU015605; dense fine speckles 70; Dfs70; Ledgf; Ledgfa; Ledgfb; Lens epithelium-derived growth factor; mLEDGF; OTTMUSP00000000056; PC4 and SFRS1 interacting protein 1; PC4 and SFRS1 interacting protein 2; PC4 and SFRS1-interacting protein; Psip1; Psip2
Gene Symbols: Psip1
Molecular weight: 59,697 Da
Basal Isoelectric point: 9.15  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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LEDGF

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene