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PLEKHG6
Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. Highest expression in the placenta. Low levels in small intestine, lung, liver, kidney, thymus and heart. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GEF; GEF, Rac/Rho |
| Chromosomal Location of mouse Ortholog: 6|6 F3 |
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Cellular Component:
cell junction; cell projection; centrosome; cytoplasm; cytoskeleton
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Molecular Function:
GTPase activator activity; guanyl-nucleotide exchange factor activity
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Reference #:
Q8R0J1
(UniProtKB)
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Alt. Names/Synonyms: BC026778; Gm155; MGC30363; OTTMUSP00000026951; PH domain-containing family G member 6; PKHG6; pleckstrin homology domain containing, family G (with RhoGef domain) member 6; Pleckstrin homology domain-containing family G member 6; Plekhg6
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Gene Symbols: Plekhg6
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Molecular weight:
89,148 Da
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Basal Isoelectric point:
7.13
Predict pI for various phosphorylation states
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| Select Structure to View Below |
PLEKHG6
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