YSK1 Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; YSK subfamily
Chromosomal Location of human Ortholog: 2q37.3
Cellular Component:  cytoplasm; Golgi apparatus
Molecular Function:  ATP binding; metal ion binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity
Biological Process:  axonogenesis; establishment of Golgi localization; establishment or maintenance of cell polarity; Golgi localization; Golgi reassembly; intrinsic apoptotic signaling pathway in response to hydrogen peroxide; positive regulation of axonogenesis; positive regulation of stress-activated MAPK cascade; protein autophosphorylation; protein phosphorylation; response to hydrogen peroxide; response to oxidative stress; signal transduction
Reference #:  O00506 (UniProtKB)
Alt. Names/Synonyms: DKFZp686J1430; serine/threonine kinase 25; serine/threonine kinase 25 (STE20 homolog, yeast); serine/threonine kinase 25 (Ste20, yeast homolog); Serine/threonine-protein kinase 25; SOK-1; SOK1; Ste20, yeast homolog; Ste20-like kinase; Ste20/oxidant stress response kinase 1; sterile 20 (oxidant stress response kinase 1); Sterile 20/oxidant stress-response kinase 1; STK25; yeast Sps1/Ste20-related kinase 1; YSK-1; YSK1
Gene Symbols: STK25
Molecular weight: 48,112 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene